Goals from Benjamin Eshun and Benedict Damlen Wobenu ensured AshantiGold reign supreme over their Adansi rivals.
Assistant coach Yakubu Sheriff Mambo made eleven changes to the previous squad that won 1-0 against Dreams FC in the premier league in midweek.
Goalkeeper Robert Dabuo, Isaac Quansah, Stephen Owusu Banahene and Eric Esso all earned starting roles for the first time this season.
Despite dominating the first half, the Miners failed to find the back of the net.
Eshun finally broke the deadlock in the 65th minute with an overhead kick.
Wobenu scored his first goal in the Gold and Black colours in the 84th minute to seal the victory for the visitors.
AshantiGold SC will know their round of 32 opponents after a draw in the coming weeks.